招生专业

海洋化学

个人详细介绍

1998年，获新奥门31999高分子研究所博士研究生学位；现任新奥门31999海洋学院教授，博士研究生导师，海洋微生物功能分子广东省高校重点实验室副主任。2003-2004年美国弗吉尼亚大学访问学者。2018,2019年两次参与“新奥门31999南海科学考察”西沙航次，并担任2019年西沙航次首席科学家。研究方向主要为海洋天然产物的发现及应用。主要从事海洋天然产物的分离提取，结构鉴定，有机合成，活性化合物的结构修饰和构效关系研究工作，先后主持和承担了863计划项目，国家自然科学基金，国家海洋公益性行业专项等10余项课题。在Tetrahedron、Organic Letter、J. Chromatogr、Planta Medica.、Mar. Drugs等杂志发表论文60余篇，获授权专利发明10余项。

联系方式：[email protected]

本课题组长期招聘具有海洋天然产物，分子生物学，化学生物学, 有机合成，酶催化，药理学背景的博士后与专职科研人员。

 

代表性科研项目

1. 国家自然科学基金：南海红树林真菌抗肿瘤活性代谢产物研究

2. 国家自然科学基金：用分子烙印技术分离手性药物对映体的研究

3. 国家公益性行业（海洋）专项：海洋微生物小分子化合物资源库构建及药源活性物质的筛选应用（子课题）

4. 高校科研基本业务费项目：南海红树林真菌BL321活性次生代谢产物的分离和结构改造

5. 广东省自然科学基金：纤维素类手性固定相分离药物对映体的研究

 

代表性学术成果

 

  1. Minghua Jiang , Heng Guo , Qilin Wu, Siwen Yuan  and Lan Liu *.Two New Picoline-Derived Meroterpenoids with Anti-Acetylcholinesterase Activity from Ascidian-Derived Fungus Amphichorda felinaMolecules .2022, 27(16), 5076;
  2. Senhua Chen, Heng Guo, Minghua Jiang, Qilin Wu, Jing Li, Hongjie Shen* and Lan Liu*.Mono-and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722[J]. Marine drugs,2022,  20(1), 51
  3. Siwen Yuan, Senhua Chen,Heng Guo, Litong Chen, Hongjie Shen, Lan Liu*and Zhizeng Gao*.Elucidation of the Complete Biosynthetic Pathway of Phomoxanthone A and Identification of a Para–Para Selective Phenol Coupling Dimerase[J]. Organic letters, 2022,24-16.
  4. Guifa Zhai, Senhua Chen* , Hongjie Shen, Heng Guo, Minghua Jiang and Lan Liu*.Bioactive Monoterpenes and Polyketides from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722 [J]. Marine drugs,2022, 20(9), 553
  5. Senhua Chen,Hongjie Shen,Yanlian Deng,Heng Guo,Minghua Jiang,Zhenger Wu,Huimin Yin,Lan Liu*. Roussoelins A and B: two phenols with antioxidant capacity from ascidian‑derived fungus Roussoella siamensis SYSU‑MS4723[J]. Marine Life Science & Technology, 2021, 3(1):69-76.
  6. Xinjian Yin, Litong Chen, Siwen Yuan, Lan Liu, Zhizeng Gao*, A robust high-throughput fluorescent polarization assay for the evaluation and screening of SARS-CoV-2 fusion inhibitors, Bioorganic Chemistry, 116 (2021) 105362.
  7. Ni Pan, Zicheng Li , Zhihong Li, Senhua Chen, Minghua Jiang , Hanyan Yang, Yaosheng Liu,Ruihu, Yuwei Zeng, Lehui Dai, Lan Liu* and Guanlei Wang*.Antiplatelet and Antithrombotic Effects of Isaridin E Isolated from the Marine-Derived Fungus via Downregulating the PI3K/Akt Signaling Pathway[J]. Marine drugs,2022, 20(1), 23
  8. Minghua Jiang, Zhenger Wu, Lan Liu* and Senhua Chen *. The chemistry and biology of fungal meroterpenoids (2009–2019)[J]. Organic & Biomolecular Chemistry.2020.19, 1644–1704
  9. Minghua Jiang,Senhua Chen*,Jing Li,Lan Liu*.The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms[J]. Marine Drugs,2020,18(2):114.
  10. Panpan Zhang,Yanlian Deng,Xiaojing Lin, Bin Chen, Jing Li, Hongju Liu, Senhua Chen,*and Lan Liu*. Anti-inflammatory Mono-and Dimeric Sorbicillinoids from the Marine-Derived Fungus Trichoderma reesei 4670[J]. Journal of natural products,2019，82(4), 947-957.
  11. Senhua Chen, Hongjie Shen, Panpan Zhang, Hongwei Cheng, Xinliang Dai*, Lan Liu*. Anti-glioma trichobamide A with an unprecedented tetrahydro-5 H-furo [2, 3-b] pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729[J].Chemical Communications, 2019, 55(10): 1438-1441.
  12. Yan Chen, Zhaoming Liu, Hongju Liu, Yahong Pan, Jing Li, Lan Liu* and Zhigang She. Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4[J]. Marine drugs, 2018, 16(2): 54
  13. Minghua Jiang , Heng Guo , Qilin Wu, Siwen Yuan  and Lan Liu *.Two New Picoline-Derived Meroterpenoids with Anti-Acetylcholinesterase Activity from Ascidian-Derived Fungus Amphichorda felinaMolecules .2022, 27(16), 5076;
  14. Senhua Chen, Heng Guo, Minghua Jiang, Qilin Wu, Jing Li, Hongjie Shen* and Lan Liu*.Mono-and Dimeric Xanthones with Anti-Glioma and Anti-Inflammatory Activities from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722[J]. Marine drugs,2022,  20(1), 51
  15. Siwen Yuan, Senhua Chen,Heng Guo, Litong Chen, Hongjie Shen, Lan Liu*and Zhizeng Gao*.Elucidation of the Complete Biosynthetic Pathway of Phomoxanthone A and Identification of a Para–Para Selective Phenol Coupling Dimerase[J]. Organic letters, 2022,24-16.
  16. Guifa Zhai, Senhua Chen* , Hongjie Shen, Heng Guo, Minghua Jiang and Lan Liu*.Bioactive Monoterpenes and Polyketides from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722 [J]. Marine drugs,2022, 20(9), 553
  17. Senhua Chen,Hongjie Shen,Yanlian Deng,Heng Guo,Minghua Jiang,Zhenger Wu,Huimin Yin,Lan Liu*. Roussoelins A and B: two phenols with antioxidant capacity from ascidian‑derived fungus Roussoella siamensis SYSU‑MS4723[J]. Marine Life Science & Technology, 2021, 3(1):69-76.
  18. Xinjian Yin, Litong Chen, Siwen Yuan, Lan Liu, Zhizeng Gao*, A robust high-throughput fluorescent polarization assay for the evaluation and screening of SARS-CoV-2 fusion inhibitors, Bioorganic Chemistry, 116 (2021) 105362.
  19. Ni Pan, Zicheng Li , Zhihong Li, Senhua Chen, Minghua Jiang , Hanyan Yang, Yaosheng Liu,Ruihu, Yuwei Zeng, Lehui Dai, Lan Liu* and Guanlei Wang*.Antiplatelet and Antithrombotic Effects of Isaridin E Isolated from the Marine-Derived Fungus via Downregulating the PI3K/Akt Signaling Pathway[J]. Marine drugs,2022, 20(1), 23
  20. Minghua Jiang, Zhenger Wu, Lan Liu* and Senhua Chen *. The chemistry and biology of fungal meroterpenoids (2009–2019)[J]. Organic & Biomolecular Chemistry.2020.19, 1644–1704
  21. Minghua Jiang,Senhua Chen*,Jing Li,Lan Liu*.The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms[J]. Marine Drugs,2020,18(2):114.
  22. Panpan Zhang,Yanlian Deng,Xiaojing Lin, Bin Chen, Jing Li, Hongju Liu, Senhua Chen,*and Lan Liu*. Anti-inflammatory Mono-and Dimeric Sorbicillinoids from the Marine-Derived Fungus Trichoderma reesei 4670[J]. Journal of natural products,2019，82(4), 947-957.
  23. Senhua Chen, Hongjie Shen, Panpan Zhang, Hongwei Cheng, Xinliang Dai*, Lan Liu*. Anti-glioma trichobamide A with an unprecedented tetrahydro-5 H-furo [2, 3-b] pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729[J].Chemical Communications, 2019, 55(10): 1438-1441.
  24. Yan Chen, Zhaoming Liu, Hongju Liu, Yahong Pan, Jing Li, Lan Liu* and Zhigang She. Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4[J]. Marine drugs, 2018, 16(2): 54
  25. New Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#. Natural product research, 2017, 31(3): 326-332.
  26.  Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#. Natural product research, 2016, 30(7): 755-760.
  27. A new Secondary metabolites of the crinoid (Comanthina schlegeli) associated fungus Alternaria brassicae 93. Natural product research, 2016, 30(20): 2305-2310.
  28. Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#. Marine Drugs, 2015,13(10): 6306-6318.
  29.  A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic Fungus Penicillium sp. Natural product research, 2015, 10(9): 1549-1551.
  30.  Meroterpenes and azaphilones from marinemangrove endophytic fungus Penicillium 303# Fitoterapia, 2014.97(9), 241-246 
  31. Alterporriol-type dimers from the mangroveendophytic fungus, Alternaria sp. (SK11), and their MptpB inhibitions. Marine Drugs, 12(5), 2953-2969, 2014
  32.  Loddigesiinols G-J: alpha-glucosidaseinhibitors from Dendrobium loddigesii. Molecules, 19(6), 8544-8555, 2014.
  33.  Studies on the Synthesis of Derivatives ofMarine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells, Marine Drugs, 10(4),  932-952, 2012.
  34.  Four eremophilane sesquiterpenes from themangrove endophytic fungus Xylaria sp. Bl321. Marine Drugs, 10:340-348,2011.、
  35.  Metabolites of Mangrove Fungus Xylaria sp.(BL321) from the South China Sea,Planta Medica. 2012, 78(2):172-176.
  36.  Synthesis and cytotoxicevaluation of eremophilane sesquiterpene S6-2 derivatives. Chem. Pharm. Bull,59(9): 1186-1189 ,2011.
  37.  Structural elucidation and NMR assignments offour aromatic lactones from a mangrove endophytic fungus (No. GX4-1B). MagneticResonance in Chemistry, 48(6):496-499,2010.
  38. . 3,3'-Functionalized octahydro BINOL:  a facilesynthesis  and  its  high  enantioselectivity  in  the  alkyne  addition  to aldehydes. Tetrahedron,2004, 60(34):7427-7430.